Prof. Dr. Imad About - Özet

Prof. Dr. Imad About | Özet

Prof. Dr. Imad About

Prof. Dr.  Imad About
Prof. Dr. Imad About

Dentin-Pulp Regeneration Update Explains How a Biomaterial Kills The Pulp or Induces Its Regeneration

Understanding dentinogenesis and pulp regeneration during physiological and pathological conditions represents a real challenge in the provision of a suitable treatment that ideally leads to the induction of the pulp regenerative potential. Carious decay and the application of dental materials onto the injured pulp/dentin modify the local microenvironment and affect the pulp regeneration potential.
Tricalcium silicate-based cements are considered as materials of choice for direct pulp capping. The continuous improvement of these materials led to the development of dentin replacement materials such as BiodentineTM which has a reduced setting time, highly improved mechanical properties and bioactive properties. These bioactive properties can be partially explained both by Calcium ion release on hydration and growth factors secretion from pulp cells. Additional modifications led to the development of light-cured, resin-modified calcium silicate-based materials.
During this conference, we will review the early steps of dentin pulp regeneration that appear critical after pulp capping procedures. Different models will be described where the interactions between different cell types illustrate their role in maintaining the pulp homeostasis. The hydration, calcium release and interaction of tricalcium silicates with dentin and pulp tissues will be reported. The consequences of modifying resins to tricalcium silicates will be discussed.
This will allow a better understanding of pulp regeneration and dentin bridge formation under direct pulp capping materials.