Prof. Dr. Gottfried Schmalz - Özet

Prof. Dr. Gottfried Schmalz | Özet

Prof. Dr. Gottfried Schmalz

Prof. Dr. Gottfried Schmalz
Prof. Dr. Gottfried Schmalz

Developments in Pulp Regeneration
Dental pulp regeneration has become possible by applying the principles of tissue engineering, using dental pulp-derived stem cells, suitable natural or synthetic matrices and a set of signaling molecules. Two approaches seem feasible: (1) mixing stem cells and recombinant growth factors with the scaffold, which then is applied into the root canal; or (2) application of the scaffold and then use/attract resident stem cells and growth factors. Extracorporeal stem cell management is afflicted with problems like genome stability and cost. Clinical studies using this approach have been initiated, but no results are available, so far. A cell-free approach relies on cell migration into the scaffold and on the activation of existing growth factors e.g. from dentin. It could be shown that EDTA is able to release or expose on the dentin surface growth factors like TGFβ1, or VEGF, which are able to stimulate pulp cell migration (cell homing). This approach is somehow followed when applying the revitalization treatment procedure, as e.g. described in AAE guidelines. Reports from single cases show clinically and radiographically successful outcomes. However, histological analyses are few and contradictory. Further studies must show whether the different approaches can lead to the generation of pulp-like tissues.